Some common heterocyclic compound, 7477-63-6, name is 7-Chloroisatin, molecular formula is C8H4ClNO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of 7-Chloroisatin
In a 100 mL round bottom flask, according to the feed ratio (7-chloroisatin: ethanol (1:1.5); 7-chloroisatin: 1-phenylmalonaldehyde (1:1.2))Add 7-chloroisatin 80 mg (0.44 mmol), ethanol 30.4 mg (0.66 mmol) and 1-phenylmalonaldehyde 78.4 mg (0.53 mmol), respectively.Adding a catalytic amount (0.1 times equivalent of 7-chloroisatin or its derivative) of 007×7, ferrocene and palladium acetate, 25 mL of solvent tetrahydrofuran, heating to 80 ° C, and heating for 6 hours.The reaction was monitored by thin layer chromatography. After the reaction was completed, the heating was stopped, the condensing device was removed, the mixed system was concentrated under reduced pressure, and purified by column chromatography.The title compound (12) was obtained by drying to give 120.8 mg,yield of 81percent.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 7477-63-6, its application will become more common.
Reference:
Patent; Shaanxi University of Science and Technology; Liang Chengyuan; Tian Danni; Ding Shunjun; Wang Xuechuan; Dong Hao; Wang Qiang; (15 pag.)CN108395438; (2018); A;,
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