Related Products of 480-91-1, A common heterocyclic compound, 480-91-1, name is Isoindolin-1-one, molecular formula is C8H7NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Intermediate 6B: [00203] Potassium nitrate (1.215 g, 12.02 mmol) was added portionwise to a solution of Intermediate 6A (1.6 g, 12.02 mmol) in sulfuric acid (24 mL) at 0 0C over 10 min. The reaction mixture was stirred to 3 h at ambient temperature. The reaction mixture was poured onto ice and the resulting precipitate was washed with water and dried in vacuo to yield Intermediate 6B (1.85 g, 10.38 mmol, 86 % yield) as a beige solid. 1H NMR (400 MHz, DMSO-d6) delta ppm 4.53 (s, 2 H) 7.86 (d, J=8.25 Hz, 1 H) 8.33 (s, 1 H) 8.45 (dd, J=8.24, 2.20 Hz, 1 H) 8.97 (s, 1 H). MS (ESI) m/z 179.0 (M+H)+.
The synthetic route of 480-91-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; WO2008/79759; (2008); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem