Adding a certain compound to certain chemical reactions, such as: 7477-63-6, name is 7-Chloroisatin, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 7477-63-6, SDS of cas: 7477-63-6
General procedure: To the respective solution of isatins 1a-g (1 mmol) inDMF(3mL) were added K2CO3 (165.5mg, 1.2 mmol). The resultingmixtures were stirred at 80 C for 1 h, then KI (8.3 mg,0.05 mmol) was added. After stirring for further 15 min,0.15mL of a solution of propargyl bromide 80% in toluenewas added dropwise slowly into the mixtures. The reactionmixtures were again stirred at 60 C for 3 h. Upon completionof the reaction, the resulting mixtures were cooled, pouredinto ice-cold water and acidified to pH?4. The orange solidsformed were filtered and dried to give the propargylatedisatins2, which were used for the next step without furtherpurification.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 7-Chloroisatin, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Dung, Do Thi Mai; Hai, Pham-The; Anh, Duong Tien; Huong, Le-Thi-Thu; Yen, Nguyen Thi Kim; Han, Byung Woo; Park, Eun Jae; Choi, Yeo Jin; Kang, Jong Soon; Hue, Van-Thi-My; Han, Sang-Bae; Nam, Nguyen-Hai; Journal of Chemical Sciences; vol. 130; 6; (2018);,
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