Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 17702-83-9, name is 2-(8-Bromooctyl)isoindoline-1,3-dione, A new synthetic method of this compound is introduced below., Quality Control of 2-(8-Bromooctyl)isoindoline-1,3-dione
General procedure: To asolution of intermediate 12 (2.0 mmol) andanhydrous K2CO3 (0.69 g, 5.0 mmol) in acetone (10 mL), pyrrolidine(2.5 mmol) was added. After reflux for 6 h until thestarting material 12 disappeared,the solvent was removed under vacuum, the residue was poured into water andextracted with EtOAc, the solution was dried over Na2SO4and then concentrated, the compounds 13 wereused without further purification.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Luo, Wen; Wang, Ting; Hong, Chen; Yang, Ya-Chen; Chen, Ying; Cen, Juan; Xie, Song-Qiang; Wang, Chao-Jie; European Journal of Medicinal Chemistry; vol. 122; (2016); p. 17 – 26;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem