Application of 1127-59-9, A common heterocyclic compound, 1127-59-9, name is 7-Methylindoline-2,3-dione, molecular formula is C9H7NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of potassium hydroxide (11.8 g, 211 mmol, 5 eq) in water (80 mL) was added 7-methylindoline-2,3-dione (6.8 g, 42.2 mmol, 1 eq) in ethanol (100 mL). The mixture was stirred at 76° C. then acetone (50 mL) was added. The mixture was heated to 76° C. for 3 days. Acetone and ethanol were removed under reduced pressure. Impurities were removed by extraction with dichloromethane. Aqueous layer was lyophilized to give 2,8-dimethylquinoline-4-carboxylic acid as a brown solid (7.05 g, 83percent).
The synthetic route of 1127-59-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; GALDERMA RESEARCH & DEVELOPMENT; OUVRY, Gilles; HARRIS, Craig Steven; BHURRUTH-ALCOR, Yushma; (65 pag.)US2017/247353; (2017); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem