Reference of 7147-90-2, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 7147-90-2 as follows.
The intermediate compound 4 (0.0165 mol) was dissolved in 40 ml of methylene chloride, cooled to 0 C in an ice bath and triisopropylchlorosilane (0.1818 mol) was added under nitrogen, triethylamine (0.0182 mol) Heated at 40 C for 6 hours and cooled to room temperature. The filter cake was washed with dichloromethane. The filtrate was washed three times with 10% hydrochloric acid solution in 20 ml, and the mixture was washed three times with 20 ml of water. The organic layer was dried over anhydrous sodium sulfate, filtered and the filtrate was steamed to remove the solvent. The residue was washed with a small amount of methanol,Filtered to a yellow solid which was used directly in the next step without purification.
According to the analysis of related databases, 7147-90-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Shandong University; Zhao Guisen; Liu Yang; Geng Jingkun; Li Yijing; (15 pag.)CN104447496; (2017); B;,
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