Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1914-02-9, name is 3,3-Dimethylindoline, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C10H13N
Example 1 N-(3,3-Dimethylindolin-1-yl)-3-(4-imidazolyl)propionamide monohydrochloride (E1) A suspension of 3-(4-imidazolyl)propionic acid monohydrochloride (2.0g) (Chem. Ber. 66 , 156 [1933]) in thionyl chloride (10ml) and DMF (3 drops) was stirred at room temperature for 3h. The excess thionyl chloride was removed by rotary evaporation and the residue re-evaporated with 2 x 50ml of dry toluene. The residue was suspended in CH2Cl2 (100ml) and a solution of 3,3-dimethyl indoline (1.7g) and triethylamine (4ml) in CH2Cl2 (50ml) was added with stirring and cooling. The reaction mixture was stirred overnight, washed with saturated NaHCO3 and the lower organic layer dried (Na2SO4). Concentration of the organic extracts afforded the crude product which was purified by column chromatography on silica, eluding with CHCl3 containing increasing quantities of methanol.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1914-02-9.
Reference:
Patent; BEECHAM GROUP PLC; EP387431; (1990); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem