Electric Literature of 100510-64-3, The chemical industry reduces the impact on the environment during synthesis 100510-64-3, name is 3,3-Dimethyl-6-nitroindolin-2-one, I believe this compound will play a more active role in future production and life.
Compound 22 (10.0 g, 0.19 mol) was dissolved in ethanol (700 mL) and dichloromethane (150 mL), concentrated hydrochloric acid (10 mL), palladium on carbon (10%, 400 mg), and hydrogen balloon were replaced 3 times. Stir at room temperature overnight. The palladium carbon was filtered off, and the filtrate was concentrated under reduced pressure. The residue was added with methyl tert-butyl ether, filtered, and dried in vacuo to obtain a yellow solid compound 23 (9.0 g, yield 87.3%).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3,3-Dimethyl-6-nitroindolin-2-one, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Suzhou Ruiming Drug Discovery Co., Ltd.; Zhang Fei; Feng Zixia; (33 pag.)CN110950868; (2020); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem