These common heterocyclic compound, 346-34-9, name is 4-Fluoroindoline-2,3-dione, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 4-Fluoroindoline-2,3-dione
General procedure: Compound 2e was prepared from 4-fluoro-1H-indole-2,3-dione 1c and dl-leucine in a similar manner to that described for the synthesis of compound 2a and obtained in 70% yield as a yellow solid. 1H NMR (400 MHz, DMSO-d6) delta 0.85-0.90 (m, 6H), 1.28-1.39 (m, 2H), 1.58-1.67 (m, 1H), 1.92-2.03 (m, 1H), 2.11-2.22 (m, 1H), 2.91-3.04 (m, 1H), 3.15 (s, 3H), 3.38-3.42 (m, 1H), 3.44-3.49 (m, 1H), 6.60-6.69 (m, 2H), 7.15-7.23 (m, 1H), 10.51 (s, 1H). MS m/z 321 (M+H)+.
The synthetic route of 4-Fluoroindoline-2,3-dione has been constantly updated, and we look forward to future research findings.
Reference:
Article in Press; Ito, Masahiro; Iwatani, Misa; Yamamoto, Takeshi; Tanaka, Toshio; Kawamoto, Tomohiro; Morishita, Daisuke; Nakanishi, Atsushi; Maezaki, Hironobu; Bioorganic and Medicinal Chemistry; (2017);,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem