Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 6326-79-0, name is 6-Bromoisatin, This compound has unique chemical properties. The synthetic route is as follows., Product Details of 6326-79-0
To a suspension of 6-bromoisatin (Richman) (5.0 g, 22.1 mmol) in water (55 ml) was added [NAOH] (0.94 g, 23.5 mmol, 1.1 equiv) and the mixture was warmed to approximately [35 C] for 30 minutes to form a solution. The solution was cooled to [5 C] and a solution of sodium nitrite (1.70 g, 24.8 mmol, [1.] [1] equiv) was added dropwise over approximately 30 minutes, keeping the temperature below 10 C. The whole mixture was added dropwise via a cannula to a vigorously stirred solution of concentrated sulphuric acid (4.48 g, 45.7 mmol, 2.0 equiv) in water (55 ml) keeping the temperature below [10 C.] The mixture was stirred for 20 minutes and a solution of tin (II) chloride (10.2 g, 54.0 mmol, 2.4 equiv) in concentrated hydrochloric acid (21 ml) was added dropwise. The mixture was stirred at [5 C] for 2 hours and the resulting crude 5-methylindazole-3-carboxylic acid was isolated by filtration and washed several times with water. The yellow solid was then azeotroped with toluene (3 x 100 ml) to remove water prior to the next step to leave a yellow/green solid. LCMS MH+ 238/240 [(79BR/8LBR),] RT 2.69 min.
According to the analysis of related databases, 6326-79-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ASTEX TECHNOLOGY LIMITED; WO2004/14864; (2004); A1;,
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