Some common heterocyclic compound, 56341-37-8, name is 6-Chlorooxindole, molecular formula is C8H6ClNO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C8H6ClNO
Step 1: 3,3-Dibromo-6-chloro-1,3-dihydro-indol-2-one At room temperature, to a solution of 6-chlorooxindole (10.0 g, 59.7 mmol) in t-BuOH (500 mL) and water (2.6 mL) was added pyridinium tribromide (57.25 g, 79 mmol, 3 eq) and the reaction was stirred for 3.5 hr. The reaction was diluted with water (500 mL) and extracted with EtOAc (3*). The combined organic extracts were washed with sat. aq. NaHCO3 (3*), dried over MgSO4, filtered and concentrated to give the title compound as a tan solid (19.66 g, 100% yield). NMR (400 MHz, DMSO-d6): consistent. MS: (API-ES+) m/z 325[M+H].
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 56341-37-8, its application will become more common.
Reference:
Patent; Wyeth; US2005/250798; (2005); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem