Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 41910-64-9, name is 4-Chloroindoline, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C8H8ClN
A ImL {2-[4-({[(2,5-dioxopyrrolidin-l-yl)oxy]carbonyl}amino)-2- (l-methyl-lH-pyrazol-5-yl)phenoxy]ethyl}carbamate in dimethylformamide (78.8 mumol) was added to 4-chloroindoline (14.52mg, 1.2eq) and stirred at room temperature for 18hr. To this was added 2.0M hydrochloric acid in ether (197 muL, 5eq) and the reaction was stirred at room temperature for 24hr (2-3 drops of concentrated hydrochloric acid was added if the deprotection was incomplete and the resulting mixture was stirred for another 24hr). The ether and hydrochloric acid were evaporated under a stream of nitrogen and the resulting material was purified by etaPLC. The proper fractions were collected and lyophilized to afford the title compound as a white solid in 43.5% yield. LCMS m/z (%) = 412 (M+eta 35Cl, 100), 414 (M+eta 37Cl, 36). 1H NMR (400 MHz, DMSO-4) delta ppm 3.10 – 3.24 (m, 4 H), 3.71 (s, 3 H), 4.13 – 4.21 (m, 4 H), 6.34 (d, /=2.02 Hz, 1 H), 6.96 (d, /=8.08 Hz, 1 H), 7.13 – 7.21 (m, 2 H), 7.48 – 7.50 (m, 2 H), 7.64 (dd, /=8.84, 2.78 Hz, 1 H), 7.81 (d, /=7.58 Hz, 1 H), 7.92 (s, 2 H), 8.63 (s, 1 H).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 41910-64-9.
Reference:
Patent; ARENA PHARMACEUTICALS, INC.; WO2007/136703; (2007); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem