These common heterocyclic compound, 675109-26-9, name is 6-Bromoisoindolin-1-one, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. HPLC of Formula: C8H6BrNO
TDI01239-1 (500 mg, 2.358 mmol) was dissolved in tetrahydrofuran (24 mL), and cooled to 0 C. Under theprotection of nitrogen, 60% NaH (236 mg, 5.895 mmol) was added to the above reaction solution, and the reaction wasperformed at room temperature for 1h after the addition. Bromoethyl acetate was then added at 0 C, and the reactionwas continued at room temperature for 2h. LC-MS indicated the reaction was complete. After completion of the reaction,ice water and IN HCl solution was added to quench the reaction, and the aqueous phase was extracted with ethyl acetate(15 mL). The combined organic phase was washed with saturated brine, dried over anhydrous sodium sulfate andconcentrated to dryness to afford TDI01239-2 (700 mg, yellow solid, yield: 99.57%). MS m/z (ESI): 298.1 [M+H].
The synthetic route of 6-Bromoisoindolin-1-one has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Beijing Tide Pharmaceutical Co., Ltd.; Zhao, Yanping; Wang, Hongjun; Li, Gong; Jiang, Yuanyuan; Li, Xiang; Zhou, Liying; Liu, Yanan; (235 pag.)EP3421465; (2019); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem