Month: May 2021

3891-07-4, name is 2-(2-Hydroxyethyl)isoindoline-1,3-dione, belongs to indolines-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. name: 2-(2-Hydroxyethyl)isoindoline-1,3-dione

0.50 g of N-(2-hydroxyethyl)phthalimide, 10 mL of thionyl chloride, 2 drops of DMF, reflux for 5.0 h.Reaction is complete, cooling, 10% NaHCO33The solution was neutralized to neutral and extracted with ethyl acetate. The organic layer was dried and desolvated to give a solid. The crude product was recrystallized to give a pale yellow solid (0.46 g), yield 83.9%.

The synthetic route of 3891-07-4 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 52537-00-5, name is 6-Chloro-2,3-dihydro-1H-indole, A new synthetic method of this compound is introduced below., category: indolines-derivatives

EXAMPLE 37 4-(6-Chloro-2,3-dihydro-indol-1-yl)-pyrido[3,4-d ]pyrimidine 4-Chloropyrido[3,4-d]pyrimidine (0.10 g, 0.60 mmol), 6-chloroindoline (0.10 g, 0.66 mmol) and pyridine (0.14 g, 1.81 mmol) were combined in DMF (1 mL) and heated at 70 C. for 3 hours. The reaction was cooled to room temperature and then added to methylene chloride (150 mL). The organic layer was washed with saturated sodium carbonate and water and then dried over sodium sulfate. The solvent was removed by rotary evaporation and the residue purified by column chromatography (silica gel, 9/2/1-CH2Cl2/hexanes/methanol) to give the title product as a pale yellow residue (0.048 g, 28%). MP 194-6 C.; LCMS: 283 (MH+).

The synthetic route of 52537-00-5 has been constantly updated, and we look forward to future research findings.

Application of 200049-46-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 200049-46-3, name is 7-Bromo-2,3-dihydro-isoindol-1-one belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below.

Using the procedure of Example 1 and Compound 19a in place of Compound Id, Compound Ic was converted to 7-(l-benzenesulfonyl-lH-indol-3-yl)-2,3-dihydro- isoindol-1-one Compound 19b, which was isolate as a white solid. 1H NMR (300 MHz, MeOD) 4.48 (s, 2H), 7.22 (dt, J = 1, 8 Hz, IH), 7.31 (dt, J = 1, 8 Hz, IH), 7.45- 7.75 (complex, 7H), 7.45-8.1 (complex, 4H); MS (ESI) m/z: 389 (MH+).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 7-Bromo-2,3-dihydro-isoindol-1-one, other downstream synthetic routes, hurry up and to see.

Electric Literature of 39603-24-2, A common heterocyclic compound, 39603-24-2, name is 5,7-Dimethylindoline-2,3-dione, molecular formula is C10H9NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a round bottom flask containing 5 ml glycerol was added respective isatin (1 mmol) and respective thiosemicarbazide/semicarbazide (1 mmol) under stirring. The temperature of the reaction was set at 40 oC and the resulting mixture was stirred till completion and progress of reaction was monitored with TLC (Hexane/EtOAc 2:1). The reaction was quenched with hot water whence glycerol got dissolved in water and the resulting insoluble solid precipitate was filtered and dried to obtain the crude product which was as good as pure (1H NMR). The aqueous phase containing glycerol was extracted with methyl t-butyl ether (4 × 25 mL) to remove any trace of organic compounds and then evaporated in vacuo to give pure glycerol which was used for the next cycle.

The synthetic route of 39603-24-2 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 20870-79-5, name is 5-Nitroindolin-2-one, A new synthetic method of this compound is introduced below., Recommanded Product: 20870-79-5

Description 1:thylene)-5-nitroindolin-2-oneIn a 35 ml microwave tube were placed 5-nttro-1,3-dihydro-2H-indol-2-one (1 mmol), pyrrole-2-carbaldehyde (1.2 mmol), piperidine (2 drops), ethanol (10 mi) and a magnetic stir bar. The vessel was sealed with a septum and placed in the microwave cavity. Initial microwave irradiation of 200 W was used, the temperature being ramped from room temperature (RT) to 150 C. Once 150 C was reached the reaction vessel was held at this temperature for 30 min by moderation of the initial microwave power. After cooling, solvent was removed in vacuo and ethyl acetate was added to the reaction mixture. The precipitate was collected by filtration and washed with ethyl acetate (2x 10 ml) to afford a yellow-brown solid. The NMR results below identify the product as the title compound D1. 1H NMR (DMSO-de) delta = 13.16 (1H, brs), 11.55 (1H, brs), 8.61 (1H, d, J = 2.5 Hz), 8.18 (1H, s), 8.08 (1H, dd, JA = 2.5 Hz, J2 – 2.2 Hz), 7.47 (1H, m), 7.06 (1H, d, J = 8.8 Hz), 6.97 (1H, m), 6.44 (1H, m). 13C NMR (DMSO-de) delta = 169.6, 144.0, 142.1, 129.6 (2C), 127.6, 126.1, 122.8, 122.6, 114.0 (2C), 112.2, 109.4.

The synthetic route of 20870-79-5 has been constantly updated, and we look forward to future research findings.

Application of 15861-30-0,Some common heterocyclic compound, 15861-30-0, name is Indoline-5-carboxylic acid, molecular formula is C9H9NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A 50 ml. RBF was charged with indoline-5-carboxylic acid (2 g, 12.3 mmol), methanol (25 ml_, 0.5 M) and H2S04 (1 mlcat.). The reaction mixture was stirred at reflux for 8 h. The methanol was concentrated under reduced pressure and the resulting residue was extracted with dichloromethane (2 x 25 ml.) and the combined organic layer was washed with sat. NaHC03 (1 x 20 ml_). The combined organic layer was dried over anhydrous Na2S04 and concentrated under reduced pressure to afford methyl, indoline- 5-carboxylate (2.1 g , 2.78 g theoretical, 75.5%). The product was used directly in the next step without further purification.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Indoline-5-carboxylic acid, its application will become more common.

Synthetic Route of 611-09-6,Some common heterocyclic compound, 611-09-6, name is 5-Nitroindoline-2,3-dione, molecular formula is C8H4N2O4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: An appropriate isatin (indole-2,3-dione) (I, 0.01 mol) was dissolved in alcohol (20 mL) and added hydrazine hydrate (99%, 0.015 mol) while shaking. The reaction mixture was stirred well, warmed on a water-bath for 10 min and left in the refrigeratorfor 3 hours. The resultant yellow crystalline solid was filtered, washed repeatedly with small portions of cold water and finally with a small quantity of cold alcohol. The product was dried and purified by recrystallization from chloroform. The compounds thus obtained were characterized by comparison with their physical constants reported in the literature.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Nitroindoline-2,3-dione, its application will become more common.

Electric Literature of 3416-57-7, These common heterocyclic compound, 3416-57-7, name is 2-(2-Oxopropyl)isoindoline-1,3-dione, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

5.5. Examples 5-13; Similar to Examples 3 and 4,5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ol was prepared using the following solvent/base combinations for the preparation of the 2-amino-4-methyl-1H-pyrrole-3-carboxamide intermediate:

The synthetic route of 3416-57-7 has been constantly updated, and we look forward to future research findings.

Electric Literature of 15362-40-0, The chemical industry reduces the impact on the environment during synthesis 15362-40-0, name is 1-(2,6-Dichlorophenyl)-2-indolinone, I believe this compound will play a more active role in future production and life.

General procedure: The desired compounds 2(a-d), 3(b-d) and 4(b-d) were procured by subjecting an equivalent mixture of compounds 9 (a-d) (1 mmol) and an active methylene compound- barbituric acid, oxindole and indolinone (1 mmol), respectively in methanol (2 mL) using catalytic amount of piperidine to microwave irradiations at 120 oC for 30 min. The reaction was monitored by TLC after every 10 min. The yellow solid obtained was filtered followed by washing with methanol and dried in air.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-(2,6-Dichlorophenyl)-2-indolinone, other downstream synthetic routes, hurry up and to see.

Electric Literature of 20870-79-5, A common heterocyclic compound, 20870-79-5, name is 5-Nitroindolin-2-one, molecular formula is C8H6N2O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

5-Nitro-1,3-dihydro-indol-2-one 30b (3.56 g, 20 mmol) was dissolved in 200 ml of acetic acid under stirring, and added with palladium on activated carbon (1.0 g, 5%) to the solution at room temperature. The reaction mixture was stirred under a hydrogen atmosphere. After thin lay chromatography showed the disappearance of starting materials, the reaction mixture was filtered, and concentrated under reduced pressure to obtain the title compound 5-amino-1,3-dihydro-indol-2-one 30c (2.04 g, yield 68.9%) as a white solid. MS m/z (ESI): 149.4[M+1]

The synthetic route of 20870-79-5 has been constantly updated, and we look forward to future research findings.