Month: May 2021

Adding a certain compound to certain chemical reactions, such as: 111992-61-1, name is 2-(3-Bromo-2,2-dimethylpropyl)isoindoline-1,3-dione, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 111992-61-1, Formula: C13H14BrNO2

Step 3A suspension of 3-(4-phenoxyphenyl)-l H-pyrazolo[3,4-d]pyrimidin-4-amine (400 mg, 1.3 mmol, 1.00 equiv), 2-(3-bromo-2, 2-dimethylpropyl)-2,3-dihydro- lH-isoindole-l ,3- dione (570 mg, 1.95 mmol, 1.50 equiv) and cesium carbonate (847 mg, 2.60 mmol, 2.00 equiv) in NMP (50 mL) was stirred at 100C for 12 h under nitrogen atmosphere. It was quenched with water (150 mL). The resulting solution was extracted with ethyl acetate (5 x 30 mL). The organic layers were combined, dried over sodium sulfate and concentrated under vacuum. The residue was applied onto a silica gel column eluting with dichloromethane / methanol (10 / 1 ). This resulted in 280 mg (41 %) of 2-(2-[[4-amino-3-(4-phenoxyphenyl)- lH-pyrazolo[3,4-d]pyrimidin-l -yl]memyl]-2-memylpropyl)-2,3-dihydro-I H-isoindole-l ,3- dione as a yellow oil.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-(3-Bromo-2,2-dimethylpropyl)isoindoline-1,3-dione, and friends who are interested can also refer to it.

Reference of 87-48-9, These common heterocyclic compound, 87-48-9, name is 5-Bromoindoline-2,3-dione, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a mixture of isatin (6a-e, 1.0 g) and hydrazine-hydrate (5 mL,~30 mmol) in ethylene glycol, potassium hydroxide (10 equiv.) was added and the resulting reaction mixturewas stirred at 110-130 C for 2-3 h (reaction monitored by TLC). The reaction mixture wascooled to room temperature, poured into ice-cold water (50 mL), acidified to pH 2 with 6N hydrochloric acid and extracted with ethylacetate (3 30 mL). The organic extracts were combined, washed with brine (15 mL), dried over sodium sulfate and concentrated in vacuo. The obtained residue was purified by column chromatography using ethyl acetate-hexane as eluents to furnish 7a-e in moderate yields.

Statistics shows that 5-Bromoindoline-2,3-dione is playing an increasingly important role. we look forward to future research findings about 87-48-9.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 3676-85-5, name is 5-Aminoisoindoline-1,3-dione, A new synthetic method of this compound is introduced below., name: 5-Aminoisoindoline-1,3-dione

Potassiumhydroxide (0.35 g,6.17 mmol) was added to a solution of 4-aminophthalimide 10 (1.00 g, 6.17 mmol) in dimethylformamide(30 mL) and the mixture was stirred at ambient temperature for 2 h. Iodomethane (0.88 g, 6.17 mmol) wasadded and it was stirred for another 18 h at the same temperature. Water (50 mL) and ethyl acetate (50 mL)was added and the resulting phases were separated. The organic phase was washed with brine, driedover sodium sulfate and concentrated in vacuum. Purification by chromatography on silica gel (Gradient:0-100% ethyl acetate in cyclohexane) afforded the title compound 11a as a yellow solid (1.00 g, 92% yield):1H-NMR (DMSO-d6): delta = 7.46 (d, J = 8.24 Hz, 1H), 6.90 (d, J = 2.00 Hz, 1H), 6.77 (dd, J = 8.24 Hz, 2.00 Hz,1H), 6.42 (br. s, 2H), 2.94 (s, 3H) ppm. 13C-NMR (DMSO-d6): delta = 168.87, 168.57, 155.27, 135.10, 125.17,117.33, 116.84, 107.42, 23.83 ppm. MS (m/z): 177 [M+ H]+.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Related Products of 132898-96-5, These common heterocyclic compound, 132898-96-5, name is 2,3-Dioxoindoline-5-sulfonyl chloride, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General Procedure: To a solution of 4 (1.32 g, 5 mmol) in CH2Cl2 (10 mL), trifloroacetic acid (10 mL) was added at 0 oC. The mixture was stirred at 0 oC for 15 min. After evaporation of the solvent in vacuo, CH2Cl2 (15 mL) and triethylamine (2 mL) were added, then a solution of 2,3-dioxoindoline-5-sulfonyl chloride (1.23g, 5mmol) in THF (25 mL) was added at 0 oC. The reaction mixture was stirred overnight at rt. Then the solvent was evaporated in vacuo, ethyl acetate (100 mL) was added, washed with water (50 mL x 2), saturated NaCl (50 mL), and dried over Na2SO4. After evaporation of the ethyl acetate, the crude product was purified by Flash column chromatograph with ethyl acetate to afford 1.27 g (68%) of 5.

The synthetic route of 132898-96-5 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 22190-33-6, name is 5-Bromoindoline, A new synthetic method of this compound is introduced below., name: 5-Bromoindoline

Step 2. tert-Butyl-5-bromoindoline-1-carboxylate (BI12); To a stirred solution of 5-bromo-indoline (3.0 g, 15 mmol) in acetonitrile (100 ml), was added DMAP (0.185 g, 1.522 mmol) and di-tert-butyl dicarbonate (3.98 g, 18.3 mmol) and the reaction was stirred at RT for 16 h. The reaction mixture was concentrated on reduced pressure to obtain a residue which was diluted with diethyl ether and washed with water and brine solution (2×). The combined ether layer was dried over anhydrous Na2SO4 and concentrated under reduced pressure to afford the crude product as a off-white solid, which was used in the next step without further purification (3.0 g).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Related Products of 667463-64-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 667463-64-1 name is 6-Bromo-1-methylindoline-2,3-dione, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

I-12.1 (15.0 g, 63 mmol) and hydrazine hydrate (30 mL, 618 mmol) are heated to 125 C. for 72 h. To the cool reaction mixture DCM is added and extracted with water and 1 M HCl. The organic layer is dried over MgSO4 and concentrated. The crystallized residue is dissolved in DCM, methanol is added and the DCM is removed in vacuo. The crystallized product is filtered by suction and washed with cold methanol. Yield 63%, m/z 226/228 [M+H]+, rt 1.16 min, LC-MS Method V001-003.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 6-Bromo-1-methylindoline-2,3-dione, and friends who are interested can also refer to it.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1914-02-9, name is 3,3-Dimethylindoline, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 1914-02-9

A mixture of 3,3-dimethylindoline (103 mg, 0.700 mmol), potassium carbonate (288 mg, 2.084 mmol), and 2-bromopropanenitrile (303 mu^, 3.506 mmol) in 2 mL CH3CN was stirred at 80C (oil bath) over night. The mixture was purified by preparative HPLC. Fractions containing product were partly concentrated and residue was extracted with 1 M NaHC03and CH2C12. Organic phases were dried over MgS04, filtered, and concentrated to give 2-(3,3-dimethylindolin-l-yl)propanenitrile (105 mg). LCMS m/z = 201.2 [M+l]+; NMR (400 MHz, CDC13) delta ppm 1.26 (s, 3H), 1.40 (s, 3H), 1.63 (d, J = 7.3 Hz, 3H), 3.05 (d, J = 8.2 Hz, 1H), 3.25 (d, J = 8.2 Hz, 1H), 4.57 (q, J = 7.3 Hz, 1 H), 6.57 (d, J = 7.9 Hz, 1H), 6.83-6.87 (m, 1H), 7.06 (dd, J1=7.4 Hz, J2= 0.8 Hz, 1H), 7.12-7.16 (m, 1H).

According to the analysis of related databases, 1914-02-9, the application of this compound in the production field has become more and more popular.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 6941-75-9, name is 5-Bromoisoindoline-1,3-dione, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 6941-75-9

Synthetic Example 3; Synthesis of 4-bromophthalamide (hereinafter abbreviated as 4-BPA); [Show Image] 4-BPA represented by the formula (21) was synthesized from 4-bromophthalimide (hereinafter abbreviated as 4-BPI) according to the following procedure (reaction formula 3) with reference to Journal of Heterocyclic Chemistry, 1995, pp. 495-498. In a 100-ml eggplant flask, 27.8017 g (0.123 mols) of 4-BPI and 60 ml of 20% ammonia water were placed followed by reaction under stirring at 23C for 48 hours. After completion of the reaction, the reaction solution in the form of a white suspension was allowed to stand at 0C for one hour, followed by filtration under reduced pressure. The resulting white solid was dried in a reduced pressure dryer at 23C or 24 hours to obtain 29.90 g (yield: 75%) of a white powder of 4-BPA. The thus obtained white powder was subjected to identification of the structure thereof from NMR spectra and confirmed as 4-BPA. 1H-NMR (ppm/DMSO-d6):delta 7.84(s, 1H), 7.78(s, 1H), 7.67(d, 1H), 7.65(d, 1H), 7.62(d, 1H), 7.43(s, 1H), 7.40(s, 1H).

According to the analysis of related databases, 6941-75-9, the application of this compound in the production field has become more and more popular.

Adding a certain compound to certain chemical reactions, such as: 603-62-3, name is 3-Nitrophthalimide, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 603-62-3, Recommanded Product: 603-62-3

To a solution of 3-nitrophthalimide (1 g, 5.20 mmol) in dry DMF (35 ml), cooled in an ice bath, NaH (60% w/w dispersion in mineral oil, 0.250 g, 6.25 mmol) was added, followed after 15 minutes by t-butyl bromoacetate (0.845 ml, 5.73 mmol). After stirring for 1 hour at room temperature, the mixture was poured into water and the resulting precipitate was washed with water and with a little amount of Et2O; after drying, tert-butyl 2-(4-nitro-1,3-dioxoisoindolin-2-yl)acetate was obtained (1.44 g, 4.70 mmol, 90% yield, MS/ESI+ 328.9 [MNa]+).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Synthetic Route of 1914-02-9,Some common heterocyclic compound, 1914-02-9, name is 3,3-Dimethylindoline, molecular formula is C10H13N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A mixture of 3,3-dimethylindoline (2.1 g, 14.26 mmol) and 2-bromoethanamine hydrobromide (3.215 g, 15.69 mmol) was heated at 122 C for 15 h. The mixture was dissolved in 2M HC1 and purified by preparative HPLC to give the title compound (1.9 g). LCMS m/z = 191.4 [M+H]+; H NMR (400 MHz, CD3OD) delta ppm 1.31 (s, 6H), 3.14 (s, 2H), 3.19 (t, J = 6.1Hz, 2H), 3.33 (t, J = 6.1 Hz, 2H), 6.60 (d, J = 7.9 Hz, 1H), 6.70-6.76 (m, 1H), 7.01-7.09 (m, 2H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3,3-Dimethylindoline, its application will become more common.