Month: May 2021

Adding a certain compound to certain chemical reactions, such as: 59-48-3, name is Indolin-2-one, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 59-48-3, Recommanded Product: Indolin-2-one

To a stirred suspension of indolin-2-one (LIII, 4.0 g, 27.0 mmol) in acetonitrile (160 mL), N-bromosuccinimide (6.24 g, 35.1 mmol) was added portion-wise at 0C under nitrogen atmosphere and then stirredfor 3 h at 15-20 C. The reaction mixture was quenchedwith ice-water (100 mL) to afford solid. The resultant solid was filteredthrough sintered funnel, washed with water and dried to afford the title compound as a solid (LIV, 6.0 g, 93%). LC-MS m/z calcd for C8H6BrNO, 210.9; found 212.0. [M+H]+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Indolin-2-one, and friends who are interested can also refer to it.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 99365-40-9, name is 6-Bromoindolin-2-one, A new synthetic method of this compound is introduced below., Product Details of 99365-40-9

To the mixture of 6-bromo-2-oxindole (5 g, 24 mmol) (Combi-blocks) and 3-chloro-2-fluorobenzaldehyde (3.7 g, 24 mmol) (Oakwood) in methanol (200 mL) was added piperidine (2 g, 24 mmol) (Aldrich) dropwise. The mixture was then heated at 80 C. for 2 h. After cooled to 4 C., the mixture was filtered and resulting precipitate was collected, dried to give E/Z-6-bromo-3-(3-chloro-2-fluoro-benzylidene)-1,3-dihydro-indol-2-one as a yellow solid (Yield 7.8 g, 94%).

The synthetic route of 99365-40-9 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 550-44-7, name is 2-Methylisoindoline-1,3-dione, A new synthetic method of this compound is introduced below., Recommanded Product: 550-44-7

c 3-Hydroxy-2-methyl-2,3-dihydroisoindol-1-one 3.4 g of potassium borohydride are added slowly to a suspension of 10 g of N-methylphthalimide in 220 cm3 of methanol under an inert atmosphere. The reaction mixture is stirred at a temperature in the region of 20 C. for 20 hours, followed by dropwise addition of 200 cm3 of distilled water. The solvent is then partially evaporated off (about 120 cm3) under reduced pressure (2 kPa) at a temperature in the region of 35 C., and the residue is diluted with 400 cm3 of distilled water. The mixture is extracted with 400 cm3 of ethyl acetate. The organic phase is dried over magnesium sulfate, filtered and then concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 30 C. 4.5 g of 3-hydroxy-2-methyl-2,3-dihydroisoindol-1-one are thus obtained in the form of a white powder melting at 130 C.

The synthetic route of 550-44-7 has been constantly updated, and we look forward to future research findings.

Reference of 7477-63-6, The chemical industry reduces the impact on the environment during synthesis 7477-63-6, name is 7-Chloroisatin, I believe this compound will play a more active role in future production and life.

General procedure: (Table 3, Entry 1): beta-Cyclodextrin (1.0 mmol) was dissolved in water (15 mL) by warming to 50-55 OC until a clear solution was formed. Then, isatin (1.0 mmol) dissolved in methanol (0.5 mL) was added followed by semicarbazide (1.0 mmol) and the mixture was stirred at 50-55 OC until the reaction was complete (as monitored by TLC). After completion of the reaction, mixture was cooled to room temperature and beta-cyclodextrin was filtered. The aqueous layer was extracted with ethyl acetate (3 x 10 ml). The combined organic layers were extracted with water, saturated brine solution and dried over anhydrous Na2SO4. The combined organic layers were evaporated under reduced pressure and the resulting crude product was purified by column chromatography by using ethyl acetate and hexane (4:6) as eluent. The aqueous layer was cooled to 5 OC to recover beta-CD (Table 1). The product was confirmed by IR, 1H 13C NMR, mass spectra.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 7-Chloroisatin, other downstream synthetic routes, hurry up and to see.

Application of 446292-07-5, These common heterocyclic compound, 446292-07-5, name is (R)-2-(2-Hydroxy-3-((4-(3-oxomorpholino)phenyl)amino)propyl)isoindoline-1,3-dione, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

This example relates to the preparation of 2-{(S)-2-oxo-3-[4-(3-oxo- morpholine-4-yl)phenyl]-oxazolidine-5-yl-methyl}-isoindol-1 ,3-dione, step b) of the process. 17.0 kg of the compound (III) obtained in example 1 , 170 kg of chlorobenzene and 8.5 kg of Nu,Nu-carbonyldiimidazole are loaded into a reactor. The mass is brought to about 100 C and maintained at this temperature for 4 hours. At the end of the reaction, the mass is cooled to 0-10 C then filtered by washing it with 34.0 kg of chlorobenzene and lastly oven-dried. 17.0 kg of the desired compound (IV) are obtained, with a reaction yield equal to 93.8%.

The synthetic route of 446292-07-5 has been constantly updated, and we look forward to future research findings.

Synthetic Route of 132898-96-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 132898-96-5, name is 2,3-Dioxoindoline-5-sulfonyl chloride belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below.

Step 1: 5′-({(2S)-2-[(Benzyloxy)methyl]pyrrolidin-1-yl}sulfonyl)-1H-indole-2,3-dione To a suspension of 2,3-dioxo-2,3-dihydro-1-H-indole-5-sulfonyl chloride (9.33 g, 38.0 mmol) in a 1:1 mixture of CHCl3:THF (410 mL) was added drop-wise a solution of (2S)-2-[(benzyloxy)methyl]pyrrolidine (8.00 g, 41.8 mmol, 1.1 eq) and N,N-diiso-propylethylamine (12.2 mL, 69.8 mmol, 1.8 eq) in chloroform (63 mL) over 1.25 hours with cooling in an ice bath under a dry N2 atmosphere. The reaction was complete (by TLC) after stirring for 1 hour at room temperature. The reaction was concentrated and purified on silica gel eluding with 50/50 Pet ether/EtOAc to give the title compound as a bright orange solid (11.8 g, 77.6% yield). NMR (400 MHz, DMSO-d6): consistent.

The synthetic route of 2,3-Dioxoindoline-5-sulfonyl chloride has been constantly updated, and we look forward to future research findings.

2307-00-8, name is 5-Amino-2-methylisoindoline-1,3-dione, belongs to indolines-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. category: indolines-derivatives

q) 2-Methyl-2,3-dihydro-1H-isoindol-5-ylamine [0413] 2.643 g 4-Amino-N-methylphthalimide was suspended in 50 ml THF and added to 1.328 g lithium aluminum hydride in 50 ml THF at room temperature. The mixture was refluxed for 3 hrs, then stirred a further 3 days at room temperature. Excess LAH was destroyed by addition of water and the mixture filtered over celite. An aqueous phase was separated and extracted with CH2Cl2. The combined organic phases were dried and evaporated. The residue was stirred with HCl in MeOH and the evaporated to yield 1.6 g of the title compound as the hydrochlorid salt.

The synthetic route of 2307-00-8 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 5332-26-3, name is 2-(Bromomethyl)isoindoline-1,3-dione, A new synthetic method of this compound is introduced below., Recommanded Product: 2-(Bromomethyl)isoindoline-1,3-dione

General procedure: A mixture of 1.02 g (7.4 mmol) of freshly calcined K2CO3, 7.0 mmol of the corresponding 2-thiouracil 1-3 and 7.7 mmol of 2-(bromomethyl)-2Hisoindole-1,3-dione in 20 mL of anhydrous DMF was stirred at room temperature for 72 h. The mixture was filtered, the fi ltrate was evaporated to dryness under reduced pressure. The precipitate of mineral salts on the filter was dissolved in 1 M. aqueous H3PO4 and the resulting solution was combined with the bottom residue. The resulting mixture was filtered. The filtercake was washed with water, and then the filtrate was extracted EtOAc (3×50 mL). The filter cake was air dried to constant weight, and the organic extract was dried over anhydrous MgSO4. The dried organic extract was evaporated to dryness under reduced pressure. The residue was mixed with the filter cake and evaporated in a mixture with toluene (3×50 mL) under reduced pressure. A crude product was obtained in the residue, which was subjected to further purification using preparative HPLC.

The synthetic route of 5332-26-3 has been constantly updated, and we look forward to future research findings.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1168150-46-6 as follows. Quality Control of (E)-Methyl 3-(methoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate

General procedure: A mixture of intermediate (3a, 3b, 6a, 6b, 10a, 10b, 11a-d, and14a-g, 1.5 mmol) and methyl (E)-3-(methoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate (1.5 mmol) in methanol (10 mL) wasstirred under reflux for 5-10 h. When TLC showed the completionof the reaction, the solution was cooled to room temperature. Theprecipitate was filtered off to give a crude product, which wasrecrystallized from methanol to provide the target compounds.

According to the analysis of related databases, 1168150-46-6, the application of this compound in the production field has become more and more popular.

Adding a certain compound to certain chemical reactions, such as: 20780-72-7, name is 4-Bromoisatin, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 20780-72-7, Recommanded Product: 20780-72-7

General procedure: A solution of 2-nitrobenzamides 1 or bis(2-nitrobenzamides) 4 (1 mmol), isatins 2 or acenaphthylene-1,2-diones 6 (1 mmol), and SnCl2*2H2O (4 mmol) in EtOH (5 mL) was stirred at reflux for 3-5 h. After this period, the TLC analysis of the mixture showed the reaction to be completed. The mixture was quenched with 3percent HCl (10 mL) and filtered to yield a crude product, which was purified by recrystallization from 95percent ethanol and DMF.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Bromoisatin, and friends who are interested can also refer to it.