Analyzing the synthesis route of C11H9NO3

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 3416-57-7, name is 2-(2-Oxopropyl)isoindoline-1,3-dione, A new synthetic method of this compound is introduced below., Recommanded Product: 2-(2-Oxopropyl)isoindoline-1,3-dione

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 3416-57-7, name is 2-(2-Oxopropyl)isoindoline-1,3-dione, A new synthetic method of this compound is introduced below., Recommanded Product: 2-(2-Oxopropyl)isoindoline-1,3-dione

N-acetonylphthalimide (1 g, 4.9 mmol) was dissolved in DMF-DMA (20 mL),Add some 4A molecular sieves.The reaction mixture was stirred at 100C under nitrogen atmosphere for 15 hours.Cooled to room temperature and filtered to give crude solid (E)-2-(4-(dimethylamino)-2-oxo-3-butenyl)isoindoline-1,3-dione (600 mg) 47.5%).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; BEIGENE, LTD; WANG, ZHIWEI; GUO, YUNHANG; (300 pag.)TWI602818; (2017); B;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem