Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 446292-08-6, name is (S)-2-((2-Oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)isoindoline-1,3-dione, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 446292-08-6
Methylamine (40% strength, 153.2 ml) was added to suspension of 2-({(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)-1H-isoindole-1,3(2H)-dione (150 gm) in methanol (1500 ml) at 25 to 30 C. The reaction mass was refluxed for 6 hr, cooled to 25-30 C., followed by slow addition of acetic acid (300 ml) reaction mass. Thereaction mass was stirred for 30 min at 25-30 C. pH of the reaction mass was adjusted to 2-3 using conc. HCl. Reaction mass was stirred for 1 hr & filtered off the solid. The solid obtained was washed with methanol (50 ml) Obtained solid dissolved in mixture of methanol (500 ml) and methylene dichloride (750 ml) by adjusting pH of reaction mass to 7-8 using triethylamine at 25-30 C. and stirred till clear solution was obtained, then adjusted the pH of reaction mass to 4-5 by using acetic acid at 25-30 C. Reaction mass was stirred for 1 h at 25-30 C. and filtered off the solid. The solid obtained was washed with methanol (50 ml) and dried under vacuum at 50 to 55 C. for 5 hr to obtain 4-{4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one hydrochloride. [Yield=92.4 gm (80%); Purity (HPLC)=98.0%]
According to the analysis of related databases, 446292-08-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Mathad, Vijayavitthal Thippannachar; Patil, Nilesh Sudhir; Niphade, Navnath Chintaman; Mali, Anil Chaturlal; Bodake, Mahendra Bhagirath; Ippar, Sharad Subhash; Talla, Rajesh; US2015/11756; (2015); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem