Related Products of 3891-07-4, A common heterocyclic compound, 3891-07-4, name is 2-(2-Hydroxyethyl)isoindoline-1,3-dione, molecular formula is C10H9NO3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Under nitrogen, to about 7.26g 38mmol N- (2- hydroxyethyl) phthalimide of THF solution was dropwise added 40mL has dropped to -10 C, contains about 2.28g 57mmol NaH in 15mL THF was added dropwise. After completing -10 C under stirring for 30min. Then 4.2mL containing about 36.2 In THF 15mL mmol 4- chloro-acetoacetate was slowly dropwise added to the above system, a solution of After completion, the reaction system was naturally warmed to room temperature and stirred overnight. Under ice-cooling, ethanol was added 4mL quenched Off the reaction, the reaction solution was slowly poured into 100mL 1mol / L hydrochloric acid and ice, the aqueous phase was extracted with ethyl acetate, The combined organic phase was washed with saturated sodium bicarbonate solution, washed successively with water, dried over anhydrous sodium sulfate, filtered, The solvent was removed rotary evaporation, and the residue was purified by column chromatography to give compound S815.93g, yield 54%
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; JiangsuSimcere Pharmaceutical Company, Ltd; JiangsuSimcere Pharmaceutical Research Co. Ltd.; Chen, Rong; Liu, Fei; Cong, Xin; Feng, Lin; Li, Haidao; Dong, Qingli; (62 pag.)CN102464608; (2016); B;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem