Application of 102359-00-2, The chemical industry reduces the impact on the environment during synthesis 102359-00-2, name is 2-Oxoindoline-5-carboxylic Acid, I believe this compound will play a more active role in future production and life.
2-Oxoindoline-5-carboxylic acid (0.470 g, 2.66 mmol), O-(benzotriazol-1-yl)-N,N,N’,N’- TETRAMETHYLURONIUM TETRAFLUOROBORATE (1. 010 g, 3.15 mmol), 1-hydroxybenzotriazole hydrate (0.417 g, 3.09 mmol) and N, N-diisopropylethylamine (0.7 ML, 4.0 mmol) were suspended in ACETONITRILE/N-DIMETHYLFORMAMIDE, (10 mL: 2 mL), and stirred at room temperature for 30 min. 2-Methoxyethanamine (0.516 g, 6.88 mmol) was added and stirring was continued for 2 h. Saturated aqueous sodium hydrogencarbonate was added (10 mL) and the solvents were removed M vacuo. The residue was purified on a silica gel column using a gradient chloroform/methanol, (100: 1 to 1: 1), as the eluent to give 0.355 g (57% yield) of the title compound as a solid : 1H NMR (DMSO-DE, 400 MHz) 8 10.59 (s, 1 H), 8.31 (m, 1 H), 7.72 (d, J = 7 Hz, 1 H), 7.71 (s, 1 H), 6.83 (d, Y= 8 HZ, 1 H), 3.51 (s, 2 H), 3.42 (m, 2 H), 3.39 (m, 2 H), 3.24 (s, 3 H); MS (ES) TIL/Z 235 (M++1).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Oxoindoline-5-carboxylic Acid, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; ASTRAZENECA AB; WO2005/27823; (2005); A2;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem