Related Products of 39755-95-8,Some common heterocyclic compound, 39755-95-8, name is 5-Methoxyisatin, molecular formula is C9H7NO3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
One mmol of the compound of the structure represented by the formula (1-3)50% by weight aqueous solution of TBHP (in such an amount that the amount of TBHP is 0.8 mmol)And 1.5 mmol of K3PO4 were addedInto 5 mL of DMSO,At 20 , 500rpm stirring speed reaction 10h,Extraction with dichloromethane,Concentration and silica gel column chromatography (volume ratio of 3:2 dichloromethane / petroleum ether mixture as eluent) to isolate and purify,The compound of the structure shown by Formula (2-3) was obtained(0.39 mmol, 78% yield).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Methoxyisatin, its application will become more common.
Reference:
Patent; Central China Normal University; Jia Fengcheng; Xu Cheng; Zhou Zhiwen; Wu Anxin; (9 pag.)CN107141292; (2017); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem