Reference of 5181-35-1, A common heterocyclic compound, 5181-35-1, name is 2-(2-Bromoethoxy)isoindoline-1,3-dione, molecular formula is C10H8BrNO3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A mixture of 1A (125 mg, 0.34 mmol), K2CO3 (140 mg, 1.02 mmol)and 1B (1.09 g, 2.04 mmol) in dry DMF (2 mL) was stirred at 70 C for 6 h. After cooling to room temperature, the solution was diluted with MeOH (30 mL). The resulting precipitate was collected by centrifugation (5000 rpm, 15 min). The solid thus obtained was dispersed in water, collected by filtration, washed with MeOH and dried in vacuo. These procedures resulted in 185 mg (73.5 %) of 1C as a yellow solid. MALDI-TOF MS (dithranol): m/z calcd for [M+Na+]: 765.72; found: 765.89. Elemental analysis: calcd for C44H30N4O8 (1C): C, 71.15; H, 4.07; N, 7.54. Found: C,71.10; H, 4.19; N, 7.79.
The synthetic route of 5181-35-1 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Yoshihara, Daisuke; Noguchi, Takao; Tsuchiya, Youichi; Roy, Bappaditya; Yamamoto, Tatsuhiro; Shinkai, Seiji; Chemistry Letters; vol. 44; 6; (2015); p. 812 – 814;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem