In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 52351-75-4, name is 6-Methoxyindoline-2,3-dione belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below. HPLC of Formula: C9H7NO3
A solution of 6-methoxyindoline-2,3-dione (1 g, 5.64 mmol, SCRC) in anhydrousN,N-dimethylformamide (40 mL) was cooled to 00 C, whereupon NaH (60 % dispersion inmineral oil, 0.264 g, 6.60 mmol) was added in one portion and the reaction was stirred for 5minutes. lodomethane (0.4 13 mL, 6.60 mmol) was added and the reaction was stirred at 0 Cfor 30 minutes. The mixture was then poured into saturated aqueous NH4C1 and extractedwith ethyl acetate. The combined organic portions were washed with water and brine, dried (MgSO4), filtered, and concentrated to give the crude product (1.079 g), which was used without further purification.
The synthetic route of 52351-75-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ABBVIE INC.; ABBVIE PHARMACEUTICAL TRADING (SHANGHAI) CO., LTD.; HARDEE, David; BREWER, Jason; HASVOLD, Lisa; LIU, Dachun; MCDANIEL, Keith; SCHRIMPF, Michael; SHEPPARD, George; (139 pag.)WO2018/188047; (2018); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem