Adding a certain compound to certain chemical reactions, such as: 6941-75-9, name is 5-Bromoisoindoline-1,3-dione, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6941-75-9, COA of Formula: C8H4BrNO2
In a stirred three-necked reaction flask, 100 g of 4-bromophthalimide, 62 g of phenol, 92 g of potassium carbonate, 6.5 g of cuprous bromide, 7 g of N, N-dimethylglycine, 200 mL of 1,4 – dioxane, in the N2 protection, the system temperature to 85 C reaction, 24 hours after the complete reaction of the raw materials, vacuum distillation of dioxane; by adding 300mL of methylene chloride dissolved products After filtration, the filtrate was evaporated to dryness, and 100 mL of methanol was added. The temperature was raised to 40 C for 1 hour. The temperature of the system was reduced to -5 to 0 C, After stirring for 5 hours, the mixture was filtered and dried to obtain 85 g of a white crystalline solid, Yield 80% HPLC purity 98%
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-Bromoisoindoline-1,3-dione, and friends who are interested can also refer to it.
Reference:
Patent; Lianhua Technology Co., Ltd.; Zou Benli; Xie Siwei; Yuan Li; Cui Yan; (22 pag.)CN107188875; (2017); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem