65826-95-1, name is 5-Methylindoline, belongs to indolines-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. HPLC of Formula: C9H11N
General procedure: To a solution of compound77(0.40g, 1.35mmol) in dioxane (2mL) were added indoline (0.3mL, 2.70mmol), triethylamine (0.37mL, 2.70mmol), and 4-dimethylaminopyridine (0.16g, 1.35mmol). The mixture was purged with nitrogen for 2min. ThenPd (dppf)Cl2.CH2Cl2 (0.11g, 0.14mmol) and Mo(CO)6(0.18g, 0.68mmol) were added and the mixture was sealed in a microwave tube and heated to 85C overnight.The reaction was monitored by TLC. Upon completion, the reaction was cooled to room temperature, and diluted with water, and extracted with EtOAc (3*20mL). The combined organic fractions were washed with brine, dried over Na2SO4, and concentrated by evaporation under reduced pressure. Purification by silica gel column chromatography (gradient elution, gradient 0 to 25% EtOAc/60-90C petroleum ether) gave compound43as a light red solid (0.38g, 1.05mmol, 78% yield).
The synthetic route of 65826-95-1 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Hu, Jianping; Wang, Yingqing; Li, Yanlian; Cao, Danyan; Xu, Lin; Song, ShanShan; Damaneh, Mohammadali Soleimani; Li, Jian; Chen, Yuelei; Wang, Xin; Chen, Lin; Shen, Jingkang; Miao, Zehong; Xiong, Bing; European Journal of Medicinal Chemistry; vol. 150; (2018); p. 156 – 175;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem