Application of 341988-36-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 341988-36-1, name is Methyl indoline-6-carboxylate belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below.
A solution of methyl indoline-6-carboxylate (42) (50 mg, 0.28 mmol) in dichloromethane (10 mL) was cooled to -30 °C, treated with triethylamine (0.04 mL, 0.3 mmol) followed by dropwise addition of acetyl chloride (0.02 mL, 0.3 mmol), and warmed to RT. The reaction mixture was quenched with water and extracted with dichloromethane. The combined organic layers were washed with water, brine solution, dried with anhydrous sodium sulfate and concentrated under reduced pressure. The residue was purified by flash-chromatography using ethyl acetate/hexane (3:7) to afford 49 mg 1-acetylindoline-6-carboxylate (43) as a white solid (80percent). 1H NMR (CDCl3, 400 MHz): 8.73 (s, 1H), 7.67 (d, 1H), 7.16 (d, 1H), 4.04 (t, 2H), 3.82 (s, 3H), 3.17 (t, 2H), 2.18 (s, 3H).); MS (electrospray): m/z = 220 [M+1].
The synthetic route of Methyl indoline-6-carboxylate has been constantly updated, and we look forward to future research findings.
Reference:
Article; Jeanguenat, Andre; Durieux, Patricia; Edmunds, Andrew J.F.; Hall, Roger G.; Hughes, Dave; Loiseleur, Olivier; Pabba, Jagadish; Stoller, Andre; Trah, Stephan; Wenger, Jean; Dutton, Anna; Crossthwaite, Andrew; Bioorganic and Medicinal Chemistry; vol. 24; 3; (2016); p. 403 – 427;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem