Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 222036-66-0, name is 5-Aminoisoindolin-1-one, A new synthetic method of this compound is introduced below., Product Details of 222036-66-0
A mixture of 5-aminoisoindolin-1-one (50mg, 0.34mmol), the compound id (172mg, 0.5 lmmol), p-toluenesulfonic acid (96mg, 0.5 lmmol), and n-BuOH (5mL) was stirred at 70°C for3 hours. The mixture was cooled and concentrated under reduced pressure; the residue was20 purified by Pre-TLC to afford the compound 8 as yellow solid (25mg, 16percent). MS: 45 1(M+H).H-NMR (DMSO-d6, 400MHz): oe 11.18 (s, 1H), 9.98 (s, 1H), 8.92 (s, 1H), 8.40 (s, 1H), 8.02 (s, 1H), 7.57-7.79 (m, 4H), 7.30 (t, 1H), 4.30 (s, 2H), 3.00 (s, 3H), 2.90 (s, 3H).
The synthetic route of 222036-66-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; JACOBIO PHARMACEUTICALS CO., LTD.; ZHOU, Wenlai; LI, Runze; GAO, Panliang; WU, Xinping; BAI, Jinlong; YANG, Guiqun; WANG, Yanping; KANG, Di; (84 pag.)WO2018/19252; (2018); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem