Some common heterocyclic compound, 21544-81-0, name is 4,6-Dimethoxyindoline-2,3-dione, molecular formula is C10H9NO4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 21544-81-0
A solution of 4,6-dimethoxyindoline-2,3-dione(0.6g, 2.89 mmol) in NaOH (33% in water, 38 mL) was headedto 70 C. H2O2(30% in water, 9.4 mL) was added to the solutiondropwise. Themixture was maintained at 70 C for 40 min. Saturated Na2S2O3solution (30 mL) was added to the abovemixture at 10 C. The reactionmixture was adjusted to pH 8with HCl and then to pH 5 with AcOH. Theprecipitate thatformed was collected, washed with water, and dried to give compound11 (188 mg, 33%).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 21544-81-0, its application will become more common.
Reference:
Article; Shao, Mingfeng; He, Linhong; Zheng, Li; Huang, Lingxiao; Zhou, Yuanyuan; Wang, Taijing; Chen, Yong; Shen, Mingsheng; Wang, Fang; Yang, Zhuang; Chen, Lijuan; Bioorganic and Medicinal Chemistry Letters; vol. 27; 17; (2017); p. 4051 – 4055;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem