Adding a certain compound to certain chemical reactions, such as: 104618-31-7, name is 2-(4-Hydroxycyclohexyl)isoindoline-1,3-dione, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 104618-31-7, Recommanded Product: 2-(4-Hydroxycyclohexyl)isoindoline-1,3-dione
[00487] To a solution of PPh3 (1 .28 g, 4.9 mmol) in THF (12 mL) was added dropwise DEAD (852 mg, 4.9 mmol) at -10C. After the white solid was appeared, compound 2-(4-hydroxycyclohexyl)isoindoline-1 ,3-dione (600 mg, 2.45 mmol) was added, followed by CH3COSH (0.35 mL, 4.9 mmol) at -10C. The mixture was stirred at room temperature overnight. TLC (PE: EA = 1 :1 ) showed the reaction was complete. The mixture was poured into water (200 mL) and extracted with EtOAc (100 mL). The aqueous layer was extracted with EtOAc (100 mL X 3). The combined extracts were dried over Na2SO4, filtered and concentrated in vacuo to give S-(4-(1 ,3-dioxoisoindolin-2-yl)cyclohexyl) ethanethioate (600 mg, 81 %) as a white solid
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(4-Hydroxycyclohexyl)isoindoline-1,3-dione, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; TOLERO PHARMACEUTICALS, INC.; XU, Yong; BRENNING, Benjamin, Gary; KULTGEN, Steven, G.; LIU, Xiaohui; SAUNDERS, Michael; HO, Koc-Kan; WO2013/13188; (2013); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem