Application of 2058-72-2, These common heterocyclic compound, 2058-72-2, name is 5-Bromo-1-methylindoline-2,3-dione, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: A solution of isatins 1 (0.6 mmol), isatylidenyl-chromanones 2 (0.4 mmol), and sarcosine (0.8 mmol) in the 12.0 mL of MeOH at reflux for the specified reaction time and monitored by TLC. Then they were concentrated in vacuo to yield the crude products, which were further purified by column chromatography on silica gel (hexane/EtOAc 8:1 3:1) to give the desired products 3.
Statistics shows that 5-Bromo-1-methylindoline-2,3-dione is playing an increasingly important role. we look forward to future research findings about 2058-72-2.
Reference:
Article; Gong, Yi; Wang, Guan-Lian; Wei, Qi-Di; Chen, Lin; Liu, Xiong-Li; Tian, Min-Yi; Yang, Jun; Feng, Ting-Ting; Zhou, Ying; Synthetic Communications; vol. 48; 9; (2018); p. 1016 – 1024;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem