Application of 317-20-4, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 317-20-4, name is 7-Fluoroisatin, This compound has unique chemical properties. The synthetic route is as follows.
132 mg (0.8 mmol) 7-fluoroisatin, 215.1 mg (0.96 mmol) 1,3-diphenyl-1,3-propanedione, 50 mL toluene and 5 mL DMF as solvent, 1 mL H2O2, and 20 mg strong acid ion exchange resin D001 as catalyst were added to a 100 mL round flask. The mixture was stirred and heated at 110 C. for 8.5 hours. The reaction was monitored with TLC. When TLC indicated that reaction was complete, heating was removed. The reaction mixture was concentrated, filtered, and purified by fresh chromatograph to obtain 190.6 mg desired product (compound 12), a yield of 64.2%. 1H-NMR (300 MHz, DMSO-d6) delta (ppm): 10.89 (1H, s), 7.68?7.85 (5H, m), 7.22?7.67 (5H, m), 7.14 (1H, d), 6.85 (1H, d), 6.75 (1H, t); 13C-NMR (75 MHz, DMSO-d6) delta (ppm): 169.2, 167.5, 153.2, 148.9, 136.5, 134.5, 132.7, 130.3, 129.2, 128.8, 127.9, 122.1, 118.4, 108.5, 100.9, 93.3; MS (ESI) for (M+Na)+: 394.1.
The chemical industry reduces the impact on the environment during synthesis 7-Fluoroisatin. I believe this compound will play a more active role in future production and life.
Reference:
Patent; SHAANXI UNIVERSITY OF SCIENCE AND TECHNOLOGY; Liang, Chengyuan; Tian, Danni; Jia, Minyi; (11 pag.)US10035808; (2018); B1;,
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