In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 199328-10-4 as follows. Recommanded Product: 199328-10-4
EXAMPLE I Methyl 1-acetyl-2-indolinone-5-carboxylate 10.5 g of methyl 2-indolinone-5-carboxylate (prepared analogously to Ogawa, Hidenori et al. in Chem.Pharm.Bull 36, 2253-2258 (1988)) are stirred in 30 ml of acetic anhydride for 4 hours at 140 C. The mixture is then left to cool, poured onto ice water and the precipitate is suction filtered. The product is washed with water once more, then taken up in methylene chloride, dried over sodium sulphate and concentrated by evaporation. Yield: 11 g (86% of theory), Rf value: 0.63 (silica gel, methylene chloride/methanol=50:1).
According to the analysis of related databases, 199328-10-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Boehringer Ingelheim Pharma KG; US6319918; (2001); B1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem