Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 912999-79-2, name is 5-Chloroisoindoline hydrochloride, A new synthetic method of this compound is introduced below., Computed Properties of C8H9Cl2N
A mixture of 2-chloro-N-(1 H-indazol-5-yl)-5 ,7-dihydro furo[3 ,4-d]pyrimidin- 4-amine (1.0 g ), ZiniI.8 g, 7.8 mmcl) and 5-chloroisoindoline hydrochloride (0.58 g, 2.6 mmol) in NMP (20 mL) was heated at 150 °C lbr 1 h. The reaction mixture was cooled to room temperature, filtrated and purified by HPLC to give the title compound (110 mg, 9.12percent). ?HNMR(400 MHz, DMSO-d6)oe 12.95(1 H, s), 8.83(1 H, s), 8.26 (1 H, s), 8.08 (1 H, s), 7.62 (1 H, d, J=8.80 Hz), 7.49 (1 H, d, J8.80 Hz), 7.34 (1 H, d, J7.60 Hz), 4.86-4.71 (8 H, m). MS (ES+) rn/e 405 (M+H).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; KADMON CORPORATION, LLC; KIM, Ji-in; LIU, Kevin; POYUROVSKY, Masha; LU, Dan; ZHU, Zhenping; WO2015/54317; (2015); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem