Synthetic Route of 875003-43-3, These common heterocyclic compound, 875003-43-3, name is 7-Fluoro-1-methylindoline-2,3-dione, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: First phenylacetylene (1 mmol) was stirred with Et3N (1 mmol) in CH3CN (5 mL) at roomtemperature. After 15-20 min, N-methyl isatin (1 mmol) and InBr3 (15 mol %)was added and the reaction mixture was stirred for 16-18 h. When N-methylisatin was completely consumed as indicated by TLC, phenyl-N-tosylmethanimine(1 mmol) was added and the reaction mixture was stirred untilthe reaction reached completion, as evidenced by TLC. Acetonitrile wasdistilled out under reduced pressure and the residue was purified by silicagel (mesh 60-120) chromatography (hexane-EtOAc) to afford thecorresponding products. Characterization data of representative compounds.
The synthetic route of 875003-43-3 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Siddiqui; Rahila; Rai, Pragati; Waseem, Malik A.; Abumhdi, Afaf A.H.; Tetrahedron Letters; vol. 56; 29; (2015); p. 4367 – 4370;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem