Electric Literature of 3416-57-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 3416-57-7, name is 2-(2-Oxopropyl)isoindoline-1,3-dione, This compound has unique chemical properties. The synthetic route is as follows.
2-((4-Methyl-2.5-dioxoimidazolidin-4-yl)methylcarbamoyl)benzoic acid [0180] Phthalimido acetone (27-1) (14.2 g, 70 mmol, 1 eq.), ammonium carbonate (23.5 g, 245 mmol, 3.5 eq), potassium cyanide (6.8 g, 105 mmol, 1.5 eq.) in EtOH (70 mL) and H2O (70 niL) were heated at 75 0C for 18 h in a sealed tube. The reaction mixture was cooled to room temperature and the volatiles were evaporated in vacuo. The reaction mixture was partitioned between ethyl acetate (150 mL) and H2O (100 mL). The aqueous phase was adjusted to pH 4 and extracted with more ethyl acetate (2 x 150 mL). Organic layers were combined, dried (MgStheta4) and concentrated in vacuo to yield the crude product (27-2), which was directly used in the next step. Yield: 12.33 g (61%). 1H-NMR (400 MHz, CD3OD^) delta 7.60-7.41 (m, 4H), 3.70 (d, IH), 3.56 (d, IH), 1.44 (s, 3H). LCMS – [M+H] m/z 292.
The chemical industry reduces the impact on the environment during synthesis 2-(2-Oxopropyl)isoindoline-1,3-dione. I believe this compound will play a more active role in future production and life.
Reference:
Patent; NOVABAY PHARMACEUTICALS, INC.; JAIN, Rakesh, K.; LOW, Eddy; FRANCAVILLA, Charles; SHIAU, Timothy P.; KIM, Bum; NAIR, Satheesh, K.; WO2010/54009; (2010); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem