Adding a certain compound to certain chemical reactions, such as: 2913-97-5, name is N-(2-Oxoethyl)phthalimide, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2913-97-5, SDS of cas: 2913-97-5
Example 12d (0.4 g, 0902 mmol) and 2-(l,3-dioxo onidQlm-2- i)acetaldehyde (0.683 g, 3 J61 mmol) were combined in tetral^drof ran (9 J02 mL) under nitrogen , cooled to 0 * C and treated drop-wise with 1M ntaniuin(I V) chloride in die hloro me thane (3 J61 mL, 3.61 mmol) to give an opaque red solution. The sotitionwas stirred for 72 hours at ambient temperature and partitioned b etween ethyl acetate and water. The organic layer was was hed with s aturated aqueous s odium chloride, dried over arLhydrous sodium sulfate, filtered and concentrated. -ificationby chromatography (siEca gel, 0.5-5percent methanol in dichloiomethane) afforded the title confound as a yellow powder (0.45 g, 81percent). NMR (500 MHz, DMS 0-^) 6 1 1.78 ^, ; = 1 S3 Hz, 1 7.93 (d, J = 1 .53 Hz, 1H), 7B1 – 7.85 (m, 4 7.76 (s, l H), 7.24 – 7.30 (m, 1 H), 721 (dd, J = 824, 1.83 Hz, 1H), 7.09 – 7.15 (m, 1H) 699 – 7.05 (m, 1 6.96 (d, J = 2.44 Hz, 1 HI 6.92 (d, J = 824 Hz, 1 HI 5.44 (dd, J = 9.92, 5 4 Hz, 1 HI 4.51 – 4.56 (m, 1H), 4.44 – 4.48 (m, 1 3.87 (dd, J = 13.28, 5.34 Hz, 1 HI 3 J66 (S, 3H), 3 2 (dd, J = 13.28, 10.22 Hz, 1H), 2.98 (s, 3H) . Xi (EpsilonXi 1+) m/z 615 (M+H) 1.
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Reference:
Patent; ABBVIE INC.; ABBVIE PHARMACEUTICAL TRADING (SHANGHAI) CO., LTD.; FIDANZE, Steven D.; LIU, Dachun; MANTEI, Robert A.; MCDANIEL, Keith F.; PRATT, John; SHEPPARD, George S.; WANG, Le; BOGDAN, Andrew; HOLMS, James H.; DIETRICH, Justin D.; MARJANOVIC, Jasmina; HASVOLD, Lisa A.; DAI, Yujia; WO2014/139324; (2014); A1;,
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