These common heterocyclic compound, 19155-24-9, name is 3,3-Dimethylindolin-2-one, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C10H11NO
EXAMPLE 10 5-Bromo-3,3-dimethyl-1,3-dihydro-2H-indol-2-one: 3,3-Dimethyl-1,3-dihydro-2H-indol-2-one (1.12 g, 6.95 mmol) was dissolved in chloroform and stirred at room temperature under nitrogen. Bromine (1.12 g) was added and the mixture was heated under reflux until HBr evolution ceased and the bromine colour was discharged from the solution. The solution was washed with sodium metabisulphite solution and sodium hydrogen carbonate solution, dried (MgSO4), filtered and concentrated to dry under reduced pressure to give 5-bromo-3,3-dimethyl-1,3-dihydro-2H-indol-2-one as a yellow solid. 1 H NMR (CDCl3) d1.39 (6H s), 6.8 (1H d), 7.3 (2H m), 7.9 (1H broad)
The synthetic route of 3,3-Dimethylindolin-2-one has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Eli Lilly and Company Limited; US5773448; (1998); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem