Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 317-20-4, name is 7-Fluoroisatin, A new synthetic method of this compound is introduced below., Formula: C8H4FNO2
198 mg (1.2 mmol) 7-fluoroisatin, 144.1 mg (1.44 mmol) 2,4-pentanedione, 50 mL THF and 5 mL DMF as solvent, 1 mL H2O2, and 14.5 mg ZnCl2 as catalyst were added to a 100 mL round flask. The mixture was stirred and heated at 85 C. for 12 hours. The reaction was monitored with TLC. When TLC indicated that reaction was complete, heating was removed. The reaction mixture was concentrated, filtered, and washed with THF to obtain 175.5 mg desired product (compound 9), a yield of 59.2%. 1H-NMR (300 MHz, DMSO-d6) delta (ppm): 10.95 (1H, s), 7.59 (1H, d), 6.89 (1H, d), 6.75 (1H, t), 2.38 (3H, s), 2.24 (3H, s); 13C-NMR (75 MHz, DMSO-d6) delta (ppm): 164.2, 161.1, 153.6, 148.8, 129.9, 126.3, 117.4, 109.9, 106.3, 92.5, 23.9, 11.2; MS (ESI) for (M+H)+: 248.1.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; SHAANXI UNIVERSITY OF SCIENCE AND TECHNOLOGY; Liang, Chengyuan; Tian, Danni; Jia, Minyi; (11 pag.)US10035808; (2018); B1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem