Synthetic Route of 3485-84-5,Some common heterocyclic compound, 3485-84-5, name is N-Vinylphthalimide, molecular formula is C10H7NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a stirred solution of 4-bromo-Lambda/-(3,4-dimethoxyphenyl)benzenesulfonamide181 (887 mg, 2.39 mmol) in dimethylformamide (20 mL) at room temperature was added vinyl phthalamide (414 mg, 2 39 mmol), Pd2dba3 (131 mg, 0.143 mmol), tri-o-tolylphosphine(87 mg, 0 287 mmol), and t?ethylamine (0 83 mL, 5.98 mmol). The resulting solution was heated to 100 0C for 16 hours prior to cooling, dilution with brine, adjustment to pH = 2 with HCI, and extraction with ethyl acetate. The combined organic extracts were dried (Na2SO4), filtered, and concentrated. The residue was purified by silica gel column chromatography using EtOAc (0-100%) in hexanes to afford 184 (285 mg, 26%) as a light yellow solid. LRMS(ESI): (calc) 464.5; (found) 465.2 (MH)+
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route N-Vinylphthalimide, its application will become more common.
Reference:
Patent; METHYLGENE INC.; WO2006/102760; (2006); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem