Electric Literature of 883-44-3,Some common heterocyclic compound, 883-44-3, name is 2-(3-Hydroxypropyl)isoindoline-1,3-dione, molecular formula is C11H11NO3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Dissolve 2- (3-HYDROXYPROPYL) ISOINDOLE-1, 3-dione (2 g, 9.74 mmol, leq) in 40 mL of dichloromethane under N2. Add sulfuric acid (780 U. L) and cool reaction mixture to – 5C. Condense isobutylene gas to a liquid using a-78C cold finger charged with dry ice and acetone. Add approximately 20 mL of the condensed liquid to the reaction mixture and slowly warm the solution to room temperature overnight while stirring. Add saturated, aqueous sodium hydrogencarbonate to the reaction mixture and extract product into the organics. Wash separated organic layer with water and dry over magnesium sulfate to give 1.969 g (77% yield) of 2- (3-TERT-BUTOXYPROPYL) ISOINDOLE-1, 3-dione as a colorless oil.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-(3-Hydroxypropyl)isoindoline-1,3-dione, its application will become more common.
Reference:
Patent; ELI LILLY AND COMPANY; WO2005/9941; (2005); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem