Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 4403-36-5, name is 2-(1,3-Dioxoisoindolin-2-yl)ethanesulfonylchloride, A new synthetic method of this compound is introduced below., Recommanded Product: 4403-36-5
To bis(4-methoxybenzyl)amine (Example 406.01, 3.37g, 13.10 mmol) and TEA (5.46 mL, 39.3 mmol) in DCM (109 mL) at 0 C was added 2-phthalimidoethanesulfonyl chloride (3.94 g, 14.41 mmol, commercially available from Matrix Scientific) slowly. The reaction was stirred at RT until complete by LCMS analysis. The reaction was diluted with a saturated solution of NaCl and extracted with DCM, dried over MgSO4, filtered and concentrated in vacuo. Purification of the residue by flash chromatography on a Versapak Spherical pre-packed silica gel column (Sigma-Aldrich, St. Louis, MO, eluent: 10-55% EtOAc/hexanes, gradient elution) provided Example 95.1 (4.04g, 62%) as a white solid after evaporation. The product was used directly in the next step without further purification.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; AMGEN INC.; CHEN, Ning; CHEN, Xiaoqi; CHEN, Yinhong; CHENG, Alan C.; CONNORS, Richard V.; DEIGNAN, Jeffrey; DRANSFIELD, Paul John; DU, Xiaohui; FU, Zice; HARVEY, James S.; HEATH, Julie Anne; HEUMANN, Lars V.; HORNE, Daniel B.; HOUZE, Jonathan; KALLER, Matthew R.; KAYSER, Frank; KHAKOO, Aarif Yusuf; KOPECKY, David J.; LAI, Su-Jen; MA, Zhihua; MEDINA, Julio C.; MIHALIC, Jeffrey T.; NISHIMURA, Nobuko; OLSON, Steven H.; PATTAROPONG, Vatee; SWAMINATH, Gayathri; WANG, Xiaodong; WANSKA, Malgorzata; YANG, Kevin; YEH, Wen-Chen; (700 pag.)WO2018/97945; (2018); A1;,
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