Reference of 3484-35-3,Some common heterocyclic compound, 3484-35-3, name is 5-Methylindolin-2-one, molecular formula is C9H9NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: To a one-neck round-bottom flask equipped with magnetic stirringwas added 6-chloro-2-indolinone (2a, 1.00 g, 6.0 mmol),vinamidinium salt 324 (2.02 g, 12.0 mmol), Et3N (1.82 g, 18.0mmol), and DMF (10 mL). The mixture was stirred for 20 h atr.t., after the reaction was complete (monitored by TLC,EtOAc/MeOH = 20:1), 30 mL EtOAc and 30 mL water was added,then the aqueous layer was extracted with 30 mL EtOAc. Thecombined EtOAc layer was washed with sat. NaCl solution (15mL) and water (15 mL) then dried over Na2SO4. After filteringthe desiccant, the solvent was concentrated under vacuum to avolume of about 5 mL. The mixture was titrated with 15 mL nhexaneto give a yellow precipitant, the solid was filtered, anddried under vacuum to give 4a (1.34 g, yield 88%), a yellowpowder, which was used in the next step without further purification;mp > 250 C.
The synthetic route of 3484-35-3 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Tian, Shaixiao; Mao, Yu; Jiang, Yongjun; Xu, Guangyu; Synlett; vol. 29; 7; (2018); p. 949 – 953;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem