Synthetic Route of 2913-97-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2913-97-5, name is N-(2-Oxoethyl)phthalimide belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below.
To a stirred solution of 2-(l,3-dioxoisoindolin-2-yl)acetaldehyde (product of step-3, 4.0 g, 21.15 mmol) in ethanol (40 mL), added hydroxylamine hydrochloride (2.930 g, 42.305 mmol) followed by sodium bicarbonate (3.55 g, 42.305 mmol) at room temperature and stirred at room temperature for 16 h. The solvent was stripped off, added water (50 mL) and extracted with ethyl acetate (2 x 100 mL). The combined organic layer was washed with water (100 mL) followed by brine, dried over sodium sulphate and concentrated under vacuum to get the title compound (3.2 g, 74percent) as an off white solid. LCMS: m/z 204.1 [M+H] +; NMR (300 MHz, DMSO-d6) delta 11.36 (s, 1H), 7.98 – 7.78 (m, 4H), 6.83 (t, / = 3.8 Hz, 1H), 4.39 (dd, / = 3.9, 0.9 Hz, 2H).
The synthetic route of N-(2-Oxoethyl)phthalimide has been constantly updated, and we look forward to future research findings.
Reference:
Patent; AURIGENE DISCOVERY TECHNOLOGIES LIMITED; CHIKKANNA, Dinesh; KHAIRNAR, Vinayak; (74 pag.)WO2016/12958; (2016); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem