99365-40-9, name is 6-Bromoindolin-2-one, belongs to indolines-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Safety of 6-Bromoindolin-2-one
NaHC03 (23 g, 283 mmol, 2.0 eq) and di-tert-butyl dicarbonate (46 mL, 212 mmol, 1.5 eq) were added to a stirred solution of 6-bromoindolin-2-one (30 g, 141.5 mmol, 1.0 eq) in THF (300 mL) at rt. The mixture was refluxed for 3 h, then cooled to rt, diluted with water (100 mL) and extracted with EtOAc (2x 100 mL). The combined organic layers were washed with brine (50 mL), dried and evaporated under reduced pressure. The raw product was purified by column chromatography [silica gel 100-200 mesh, PE/EtOAc = 9:1]. White solid. Yield: 35 g, (79%). 1H NMR (400 MHz, CDCI3, delta ppm): 8.03 (d, J = 1.2 Hz, 1H), 7.27 (dd, J = 8.0, 1.6 Hz, 1H), 7.12 (d, J = 8.0 Hz, 1H), 3.58 (s, 2H), 1.64 (s, 9H).
The synthetic route of 99365-40-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; GRUeNENTHAL GMBH; KONETZKI, Ingo; JAKOB, Florian; WAGENER, Markus; WELBERS, Andre; HESSLINGER, Christian; (168 pag.)WO2017/108204; (2017); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem