Synthetic Route of 7699-18-5,Some common heterocyclic compound, 7699-18-5, name is 5-Methoxyindolin-2-one, molecular formula is C9H9NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: 4.4.18 (Z)-5-methoxy-3-((2-(3,4,5-trimethoxyphenyl)-1H-benzo[d]imidazol-6-yl)methylene)indolin-2-one (5r) Compound 5r was prepared according to the method described for compound 5a, employing aldehyde 11e (156 mg, 0.5 mmol) and 5-methoxyindolin-2-one (12b, 81 mg, 0.5 mmol) to obtain the pure product 5r as a yellow solid (134 mg, 59%); mp: 168-166 C; IR (KBr): 3425, 3174, 2354, 1690, 1640, 1575, 1488, 1435, 1280, 1120, 1032, 992, 846, 742 cm-1; 1H NMR (300 MHz, DMSO-d6): delta 10.34 (bs, 1H), 7.89 (s, 1H), 7.77 (s, 1H), 7.66 (d, J = 8.1 Hz, 1H), 7.58 (s, 1H), 7.54 (s, 2H), 7.36 (s, 1H), 6.89-6.66 (m, 2H), 3.92 (s, 6H), 3.76 (s, 3H), 3.62 (s, 3H); 13C NMR (75 MHz, CDCl3 + DMSO-d6): delta 168.9, 153.7, 153.0, 139.0, 137.3, 136.3, 128.2, 127.7, 126.2, 124.8, 121.9, 114.2, 113.8, 111.2, 111.1, 110.0, 108.9, 108.5, 103.8, 59.9, 55.8, 55.0; MS (ESI): m/z 458 [M + H]+; HRMS (ESI) calcd for C26H24O5N3 m/z 458.16992 [M + H]+; found 458.17105.
The synthetic route of 7699-18-5 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Kamal, Ahmed; Nagaseshadri; Nayak, V. Lakshma; Srinivasulu, Vunnam; Sathish, Manda; Kapure, Jeevak Sopanrao; Suresh Reddy; Bioorganic Chemistry; vol. 63; (2015); p. 72 – 84;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem