Some common heterocyclic compound, 19155-24-9, name is 3,3-Dimethylindolin-2-one, molecular formula is C10H11NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 19155-24-9
Step 4:3,3-dimethyl-2,3-dihydro-1H-indoleUnder a nitrogen atmosphere a solution of 6.20 mL (6.20 mmol) of a 1M solution lithium aluminium hydride in THF and 10 mL THF was slowly added dropwise to 1.00 g (6.20 mmol) 3,3-dimethyl-1,3-dihydro-indol-2-one in 50 mL THF.Then the reaction mixture was heated to 60¡ã C. for 1 h.After cooling to 0¡ã C., 3 mL ice water were slowly added dropwise.20 g sodium sulphate were added and the mixture was suction filtered.The solution was evaporated down i. vac.Yield: 0.80 g (88percent of theory)ESI-MS: m/z=148 (M+H)+
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 19155-24-9, its application will become more common.
Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; US2011/195954; (2011); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem