Synthetic Route of 25128-35-2, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 25128-35-2 as follows.
Step 1: 2-amino-3-(methoxycarbonyl)benzoic acidTo a solution (0.4 M) of 2,3-dioxoindoline-7-carboxylic acid (1 eq.) in MeOH, HCl gas was bubbled and the reaction mixture was stirred at 800C for 2 h. After evaporation of the solvent, the resulting residue was diluted with CHCI3, washed with aqueous NaHC?3 (saturated solution), brine and dried. Evaporation of the solvent afforded a crude (MS (ES+) m/z 206 (M+H)+) that was dissolved in H2O2 (10%). To the resulting solution (0.2 M) was added an equal volume of aqueous NaOH (2.5% solution) and the reaction mixture was stirred at RT for 15 min. The reaction mixture was acidified with cone. HCl and the resulting precipitate was filtered off and washed with water to afford (88%) the title compound as white powder. 1H NMR (400 MHz, DMSO-ds, 300K) ? 3.82 (s, 3H), 6.60 (t, IH, J 7.4), 8.04 (m, 3H), 12.94 (bs, IH); MS (ES+) m/z 196 (M+H)+.
According to the analysis of related databases, 25128-35-2, the application of this compound in the production field has become more and more popular.