Reference of 7699-18-5, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 7699-18-5, name is 5-Methoxyindolin-2-one, This compound has unique chemical properties. The synthetic route is as follows.
Example A lOO. (l R*.2S*V5′-methoxy-l’-methyl-2-(3-(4-(4-methylpiperazin-l- vDphenv?-l H-indazol–v?spirofcvclopropane-U’-indolini^’-one Sigma^^-trifluoroacetateA . 5-methoxy- 1 -methylindolin-2-oneA dry round-bottom flask was charged with NaH (60% wt) (64 mg, 1.61 mmol) and toluene (2.0 mL). The suspension was heated to 100 0C and then 5-methoxyindolin-2- one (250 mg, 1.53 mmol) was added. After 30 min at 100 0C, Me2SO4 (0.16 mL, 1.68 mmol) was added and the temperature maintained at 1000C for 2.5 h. The reaction was cooled to room temperature and the solvent was removed in vacuo. The residue was purified by column chromatography (silica gel, hexanes/EtOAc, 3: 1 to 2:1) to give the product as a beige solid (144mg, 53%); MS ESI 164.1 [M + H]+, calcd for [C9H9NO2 +H]+ 164.07.
The chemical industry reduces the impact on the environment during synthesis 5-Methoxyindolin-2-one. I believe this compound will play a more active role in future production and life.