Related Products of 120266-80-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 120266-80-0, name is 5-Aminoindolin-2-one hydrochloride belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below.
5-lsothiocyanato-1 ,3-dihydro-indol-2-oneTo a stirring solution of 5-amino- ,3-dihydro-indol-2-one hydrochloride (2 g, 10.83 mmol) and diisopropylethylamine (4.19 g, 32.49 mmol) in drydichloromethane (100 ml) at 0 C under N2, thiophosgene (1.49 g, 10.83 mmol) in dichloromethane is added dropwise and stirred for 30 minutes. The reaction mixture is quenched with water (100 ml) and the layers are separated, the organic layer is washed with water (50 ml X2) and dried over anhydrous MgS04 to get the product as brown crystalline solid (2.03 g, 99.02 %); TLC: chloroform/methanol (9.5/0.5) Rf- 0.5;1H-NMR (400 MHz, DMSO-d6): delta [ppm] 10.60 (s, 1H), 7.31 (s, 1 H), 7.25 (d, J = 7.88 Hz, 1H), 6.82 (d, J = 8.24 Hz, 1 H), 3.50 (s, 2H
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Aminoindolin-2-one hydrochloride, other downstream synthetic routes, hurry up and to see.