Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 106352-01-6, name is 3-((1,3-Dioxoisoindolin-2-yl)methyl)benzoic acid, A new synthetic method of this compound is introduced below., Application In Synthesis of 3-((1,3-Dioxoisoindolin-2-yl)methyl)benzoic acid
To 3-(1 ,3-Dioxo-1,3-dihydro-isoindol-2-ylmethyl)-benzoic acid (300 mg, 1.066 mmol) in DCM (1 mL9 are added at O0C triethylamine (164 uL, 1.173 mmol) and ethylchloroformate (112 uL, 1.173 mmol). After stirring at O0C during 15 min and filtration, the obtained solution is added at 0C to NaBH4 (61 mg, 1.599 mmol) in water (400 uL) before stirring at 00C during 30 min and at rt during 2h. The solution is acidified to pH 3 with an aqueous 1N HCI solution, extracted with ethylacetate, the organic phase is dried and evaporated to give a crude compound before purification by flash chromatography on silica gel (eluent: cyclohexane/ethyl acetate 9/1 to 1/1) to yield a colorless gum. TLC, Rf (cyclohexane/ethyl acetate 1/1) = 0.15.
The synthetic route of 106352-01-6 has been constantly updated, and we look forward to future research findings.